care and handling of laboratory animals

Guidelines for the care and use of mammals in neuroscience and behavioral research. All procedures carried out on nonhuman animals are to be reviewed by an institutional animal care and use committee (IACUC) to ensure that the procedures are appropriate and humane. A research animal observed to be in a state of severe distress or chronic pain that cannot be alleviated and is not essential to the purposes of the research should be euthanized immediately (AVMA, 2007). It is important to recognize that this document constitutes “guidelines,” which serve a different purpose than “standards.” Standards, unlike guidelines, require mandatory compliance, and may be accompanied by an enforcement mechanism. Whenever reasonable, psychologists are encouraged to first test the painful stimuli to be used on nonhuman animal subjects on themselves. 6Department of Pharmacology 7. The importance of laboratory animals being habituated to handling early on, and the fact that even simple manipulations can cause stress if the animals are not used to handling, has been known and recommended for a long time (Kvetnansky . Washington, DC: The National Academies Press. A program of animal care and use includes multiple components that work synergistically to support activities involving laboratory animals. Taking an animal’s temperature 2. Procedures involving more than momentary or slight aversive stimulation, which is not relieved by medication or other acceptable methods, should be undertaken only when the objectives of the research cannot be achieved by other methods. Note that students MUST be experienced and comfortable with basic handling and restraint of … Surgical procedures, because of their invasive nature, require close supervision and attention to humane considerations by the psychologist. COVID-19 resources for psychologists, health-care workers and the public. It is the Policy of the Public Health Service (PHS) to require institutions to establish and maintain proper measures to ensure the appropriate care and use of all animals involved in research, research training, and biological testing activities (hereinafter referred to as "activities") … Laboratory animal allergies are associated with the inhalation of allergens, such as animal dander and urinary proteins, into the lungs. 18.12.5 Animal Handling. Washington, DC: APA. Roundtable on Science and Welfare in Laboratory Animal Use This roundtable brings together representatives from government, industry, animal advocacy groups, professional societies, and academic institutions to discuss science- and welfare-related issues dealing with the use of animals … Institutions should employ people trained in laboratory animal science or provide for both formal and on the job training to ensure effective implementation of the programm. The NRCT has issued the Institutional of Animal Care and Use Committee Standard in … AWI provides funding to laboratory personnel to conduct research focused on improving the housing and handling of animals in research, and has been at the forefront of efforts to provide nonhuman primates with social housing which addresses their behavioral needs to the greatest extent possible. Washington, DC: US Government Printing Office. In this course, which is approved by the Dutch government, you learn how to use the 3Rs (replace, reduce and refine) when setting up and carrying out animal experiments. The use of appropriate and skilled handling is essential to ensure that animals readily accept or actively seek human contact and procedures are carried out efficiently. These guidelines are not intended to be mandatory, exhaustive, or definitive and should not take precedence over the judgment of individuals who have competence in the subject addressed. Disposal of euthanized laboratory animals must be conducted in accord with all relevant legislation, consistent with health, environmental, and aesthetic concerns, and as approved by the IACUC. Morrison, A. R., Evans, H. L., Ator, N. A. All over the world, animal models are used in pre-clinical research to learn more about how the body works, and to identify causes and develop treatments and cures for disorders and diseases. In C. K. Akins, S. Panicker, & C. L. Cunningham (Eds.). Handling and restraint Laboratory animals are inevitably subjected to human contact throughout their lives, during both husbandry and experiments. American Veterinary Medical Association (2007) AVMA Guidelines on Euthanasia (PDF, 550KB). Essential responsibilities seen on an Animal Care Technician resume sample are cleaning cages, feeding animals, providing drinking water, administering medicine, maintaining required environment conditions, and collecting data. From the earliest days of the organization, AWI has worked to foster better care and handling of animals in research facilities by encouraging laboratory personnel to provide the animals with comfortable housing with conspecifics; veterinary treatment including pain relief; and the opportunity to engage in species-typical behaviors—while sparing them needless suffering. Psychologists conducting field research should disturb their populations as little as possible, while acting consistent with the goals of the research. THE NATIONAL ACADEMIES PRESS 500 Fifth Street, NW Washington, DC 20001. National Research Council (2008). As a field of study, psychology examines a broad range of research and applied areas. Questions about these guidelines should be referred to the APA Committee on Animal Research and Ethics (CARE) via email, by phone at (202) 336-6000, or in writing to the APA Science Directorate, Office of Research Ethics, 750 First St., NE, Washington, DC 20002-4242. Offering needed clarity and insight into legislation from numerous regions of the world, this book provides the information in easily accessible, readable language." Dess, N. K. & Foltin, R. W. (2004). Common Laboratory Animals and Handling Techniques Anuja.M.K. The USDA and local ordinances should be consulted for information regarding regulations and approved suppliers. The IACUC is charged with warranting that the university “ensure that all scientists, research technicians, animal technicians, and other personnel involved in animal care, treatment, and use are qualified to perform their duties. Act as a resource center for the faculty on all issues relating to laboratory animals. Current Protocols in Immunology is a comprehensive source for protocols and overviews in the field of immunology including, in vivo and in vitro assays to study lymphocyte cells, the isolation and differentiation of stem and progenitor cells, flow cytometry and cell sorting, and animal models of infections disease. Psychologists should adjust the parameters of aversive stimulation to the minimal levels compatible with the aims of the research. Animal handling requires proper care for which only technical personnel are hired. In the U.S., under the provisions of the Animal Welfare Act and the Guide for the Care and Use of Laboratory Animals (the Guide), published by the National Academy of Sciences, any procedure can be performed on an animal if it can be successfully argued that it is scientifically justified. 1st Year ANIMAL HANDLING TECHNIQUES 2. Members on the committee were Gary Dunbar, PhD, Jennifer Higa, PhD, Theresa Jones, PhD, Barbara Kaminski, PhD, Scott Robinson, PhD, Rodney Swain, PhD, Pamela Scott-Johnson, PhD, Eric Wiertelak, PhD, and Sangeeta Panicker, PhD (Staff Liaison). Rahul Maheshwari, ... Rakesh K. Tekade, in Dosage Form Design Parameters, 2018. Such uses must be compatible with the goals of the research, sound scientific practice, and the welfare of the animal. National Institutes of Health Office of Laboratory Animal Welfare (2002). Basic mouse care and maintenance | protocol. National Research Council (2003). Federal Register, 54(168), (Aug 31, 1989), 36112-36163. U. S. Department of Agriculture (2000) Field study; Definition; Final Rule. Canada’s Code development processis led by NFACC. Any deviations from these SOPs must be authorized and recorded by the Study Director. § 2131 et seq. Data’s of Laboratory Animals: Table 18.1 shows important data’s on some of the animals. Chapter 6 - Training in Care, Handling, and Use of Laboratory Animals . OBJECTIVES To provide basic concept of animal handling to new user. 89–544) was signed into law by President Lyndon B. Johnson on August 24, 1966. Violations of the Ethical Principles of Psychologists and Code of Conduct by an APA member should be reported to the APA Ethics Committee by phone at 202-336-5930, or in writing to the APA Ethics Office, 750 First St., NE, Washington, DC  20002-424. In animal experiments the well-being of laboratory animals is most important. Bethesda, MD: NIH. They are informed by Section 8.09 of the Ethical Principles of Psychologists and Code of Conduct (APA, 2010). Public Health Service policy on the humane care and use of laboratory animals. To comply with the Animal Welfare Ordinance and avoid mishandling of animals in research. A respected resource for decades, the Guide for the Care and Use of Laboratory Animals has been updated by a committee of experts, taking into consideration input from the scientific and laboratory animal communities and the public at large. 1st Year ANIMAL HANDLING TECHNIQUES 2. You can minimize your risk of injury by following these animal handling safety guidelines: Approach All Animals With Caution . The rabbit is picked up from cage with the ears by one hand in a firm grip and another hand is placed under the hind-quarters to support the weight and then lifted gently. Roundtable on Science and Welfare in Laboratory Animal Use This roundtable brings together representatives from government, industry, animal advocacy groups, professional societies, and academic institutions to discuss science- and welfare-related issues dealing with the use of animals in research. Return of any wild-caught animal to the field also carries risks, both to the formerly captive animals and to the ecosystem. Psychologists should make every effort to ensure that those responsible for transporting the nonhuman animals to the facility provide adequate food, water, ventilation, space, and impose no unnecessary stress on the animals (NRC, 2006). International Standards for the Care and Use of Laboratory Animals . The Guide for the Care and Use of Laboratory Animals provides a framework for the judgments required in the management of animal facilities--a resource of proven value, now updated and expanded. Postoperative monitoring and care, which may include the use of analgesics and antibiotics, should be provided to minimize discomfort, prevent infection and promote recovery from the procedure. Instructors for these small group sessions are certified laboratory animal technologists and therefore provide a good opportunity for learning basic skills. Procedures involving the use of paralytic agents without reduction in pain sensation require particular prudence and humane concern. Animal care personnel are required to wear PPE while at work and are expected to change PPE as often as necessary to maintain a clean appearance and prevent contamination to other areas of the facility. Posted on 6/24/2019. National Research Council (2006). The committee must have representation from within the institution and from the local community. Research on nonhuman animals may not be conducted until the protocol has been reviewed by an appropriate animal care committee; typically, an Institutional Animal Care and Use Committee (IACUC), to ensure that the procedures are appropriate and humane. These guidelines are scheduled to expire 10 years from February 24, 2012 (the date of adoption by the APA Council of Representatives). The acquisition, care, housing, use, and disposition of nonhuman animals in research must be in compliance with applicable federal, state, and local, laws and regulations, institutional policies, and with international conventions to which the United States is a party. Although allergies may be … 1.2 Handling: how is it relevant and why is it important. Research conducted in populated areas must be done with respect for the property and privacy of the inhabitants of the area. Multiple surgeries on the same animal must be justified and receive approval from the IACUC. Public Health Service policy on the humane care and use of laboratory animals. Because of this requirement, usually the researcher's lab personnel take care of the animals (e.g., become animal handlers). Cleanliness 4. Phs policy on humane care and use of laboratory animals | olaw. The IACUC has a vital role in the development of laboratory animal programs in their institutions as well as ensuring ethical care and use of laboratory animals in each research project. Standard Operating Procedures for equipment use, maintenance, and calibration; for laboratory tests and methods; animal use issues such as identification, care, transfer, and necropsy; histopathology; handling test and control articles; data handling and storage. While global research goals may be similar, there are significant differences between … First, physical injuries occur from bites and scratches, especially from rodents, rabbits, dogs and cats. Experimental procedures that require prolonged aversive conditions or produce tissue damage or metabolic disturbances require greater justification and surveillance by the psychologist and IACUC. Public Health Service policy on the humane care and use of laboratory animals. Ventilation 8. APA members working outside the United States must also follow all applicable laws and regulations of the country in which they conduct research. Proper restraint and handling techniques are essential for reducing stress to laboratory animals, while at the same time allow animal care workers to perform their work with less chance of being scratched, bitten, kicked, etc. (Eds.). Retrieved September 19, 2011. American Psychological Association. DAA-AU-2015-0032-0002 . 3. Trypan Blue Exclusion Test of Cell Viability, Dextran Sulfate Sodium (DSS)‐Induced Colitis in Mice, The Isolation and Characterization of Murine Macrophages. Provide quality care for all animals used at the University of California, San Francisco. Information and permit applications can be obtained from the Fish and Wildlife Service website. Other laws, policies, and guidelines may include additional species coverage or specifications for animal care and use, … Laboratory Primate Newsletter Occupational Health and Safety in the Care and Use of Research Animals - National Research Council, 1997. Ministry of Health, Labor and Welfare dated June 1, 2006 ). The Author(s) 2019 ... burden on animal care staff time and on resources. Whenever possible behavioral procedures should be used that minimize discomfort to the nonhuman animal. If routine handling procedures are aversive, animals are likely to develop anxiety Cages 6. Laboratory Animal Practitioner, Sep-14 "This is the only publication to offer a compilation of standards across the world in the care, welfare and use of animals in research, testing, and education. Animal Handling Techniques 1. To ensure their humane treatment and well-being, laboratory animals generally may not be released from institutional facilities. laboratory animals 1. laboratory animals mehul ramanlal chorawala department of pharmacology k. b. institute of pharmaceutical education and research a constituent college of kadi sarva vishwavidyalaya gh-6, sector-23 gandhinagar-382023, gujarat laboratory animal observation, record keeping and house keeping. Field research, if strictly observational, may not require animal care committee approval (USDA, 2000). Adopted by the APA Council of Representatives on February 24, 2012. Animal Care Technicians are found in clinical and research settings and are responsible for caring for laboratory animals. In proposing a research project, the psychologist should be familiar with the appropriate literature, consider the possibility of non-animal alternatives, and use procedures that minimize the number of nonhuman animals in research. Although handling is not standardized across labs, consistent gentle handling allows for less challenging behavioral testing, better data collection, and overall improved animal welfare… 18.1): Handling: Animals should be handled with care. Practical animal handling rodents and rabbit. Field research that carries a risk of materially altering the behavior of nonhuman animals and/or producing damage to sensitive ecosystems is subject to IACUC approval. Noise is unavoidable in an animal care facility, but should be minimized. II. Laboratory animals in research and teaching: Ethics, care, and methods. Inquiries about these guidelines should be made to the American Psychological Association, Science Directorate, Office of Research Ethics, 750 First Street, NE, Washington, DC 20002, or via email. International Standards for the Care and Use of Laboratory Animals. et al., 2004; Castelhano & Baumans, … The ethics cascade. Every effort should be made to minimize potential harmful effects of the study on the population and on other plant and animal species in the area. Laboratory Animal Medical Research Involving Animal Subjects NOT Conducted IAW FDA Regulations/ RN 40-33b/1200-06 . 4. Fluid 2. Guide for the care and use of laboratory animals. Retrieved April 8, 2010. National Institutes of Health Office of Laboratory Animal Welfare (2002). Such research on endangered species should not be conducted unless IACUC approval has been obtained and all requisite permits are obtained (see IV.D of this brochure.). Insect pests 4. Purposes only after review by an IACUC or committee appropriate to the use of animal! The University of California, San Francisco. ) comply with the goals of the area a scientific... Animal to the possibility of using non-animal alternatives be discarded until its death is verified,... Information regarding regulations and guidelines and surveillance by the animal care staff and... 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